Figure 3: Allosteric coupling in nuclear receptors. A. Schematic representation of a NR-DNA-coregulator complex with individual domains, coregulator and DNA response element labeled. Allosteric coupling has been demonstrated between B. ligand-and-DNA (gray); C. DNA and coregulator (gray); D. ligand and ligand (gray) in a NR dimer, and E. DNA and the NTD (gray).