Figure 12: Allosteric surfaces and networks in SRs. A) The BF-3 surface on AR, formed by residues (green) on H1, H9 and the H3-H4 loop, B) ET1, a possible allosteric site in SRs, identified by the evolutionary trace method. ET1 is composed of 9 residues located on H1,H5,H8,H7 and H10. C) NR allosteric network (NR-AN) identified by statistical coupling analysis (SCA). The network is composed of 27 residues and links all the functional surfaces located on the LBD.