Figure 10: Proposed alternate binding cavities in SRs. A) PBS1 cavity (gray) in AR identified by docking, showing adjacency to the LBP with DHT bound [107]. B) Proposed binding cavity (gray) for DBT in GR, also adjacent to the dex-bound LBP. DBT co-binds with dex, but rearrangement of ASN564 in LBP potentially destabilizes bound dex [114].