|Figure 3: SR1988 displays a receptor stabilisation profile typical of PPARγ partial agonists.
HDX data for the corresponding peptides are plotted over the structures of PPARγ LBD
bound to rosiglitazone (PDB 2PRG) and SR1988 (PDB: 6D3E). Percentage reduction (average
of all replicates and all time points) in HDX relative to apo receptor is coloured
according to the key. Residues are coloured to correspond to the average percent change
in deuteration between apo and SR1988 or rosiglitazone bound PPARγ LBD.