Table 1: The pathology and steroid responses for nephrotic syndrome. MCD, minimal change disease; FSGS, only include primary (idiopathic); MN, (primary) membranous nephropathy; IgAN, IgA nephropathy; IST, immunosuppressive therapy; Effective, means decreased proteinuria and/or slowing the progression of renal function.


Pathology Steroid response

MCD foot processes effacement Very good
FSGS foot processes effacement and perihilar or sclerosis Effective but may need other IST; relapse and resistant occurs
MN Subepithelial deposition of the basement membrane on the outer surface of the capillary wall. Effective, in combination with other IST
IgAN IgA immune complex deposition in the mesangium Effective, but with significant adverse effects