Figure 1: The GR family proteins. Human GR harbors three functional domains: N-terminal domain (NTD), middle DNA-binding domain (DBD) and the C-terminal ligand-binding domain (LBD). The DBD and LBD are linked by the hinge region (HR). Alternative splicing of the NR3C1 (gene encoding GR) gene generates the isoforms GRα, GRβ, GRγ, GR-A, and GR-P, which differ in size and sequence of HR and/or LBD.