Table 1: The Orphan Receptor Subfamily.


Unified Nomenclature Common Abbreviations Date Identified Discovered By Ligand

NR3B Nreb1/ ERRα 1988 [ 84 ]
Nr3b2/Errβ 1988 [ 84 ]
Nr3b3/Errγ 1998 [ 109 ]
NR4A Nr4a1/Nur77 ( Ngfi-b, Tr3, N10, Nak-1, St-59), 1988 [ 85 , 111 ]
Nr4a2/Nurr1 ( Rnr-1, Not, Tinur) 1992 [ 112 ]
Nr4a3/Nor1 ( Tec, Minor, Chn) 1995 [ 113 ]
NR2F Nr2f2/Coup-tfII 1988 [ 114 ]
Nr2f6/Ear2 1988 [ 114 ]
Nr2f1/Coup-tfI 1989 [ 115 ]
NR2C Nr2c1/Tr2 1988 [ 116 ]
Nr2c2/Tr4 1994 [ 117 ]
NR1D Nr1d1/Rev-erbα 1989 [ 118 ] Heme [ 119 , 120 , 121 , 122 ]
Nr1d2/Rev-erbβ 1994 [ 123 ]
NR2B Nr2b1/Rxrα 1990 [ 90 ] 9-CIS retinoic acid as well as interacting with other NR [ 89 , 124 , 125 , 126 , 127 ]
Nr2b2/Rxrβ 1991 [ 128 ]
Nr2b3/Rxrγ 1991 [ 129 ]
NR2E Nr2e1/Tlx 1990 [ 130 ]
Nr2e3/Pnr 1999 [ 131 , 132 ]
NR1C Nr1c1/Pparα 1990 [ 85 ] Fatty acids [ 133 , 134 ]
Nr1c2/Pparβ or δ 1993 [ 135 ]
Nr1c3/Pparγ 1993 [ 135 ]
NR5A Nr5a/Sf1 1992 [ 136 ] Phospholipids [ 137 ]
Nr5a2/Lrh1 1992 [ 138 ]
NR1F Nr1f1/Rorα 1993 [ 139 ] Sterols ?
Nr1f2/Rorβ 1993 [ 139 ]
Nr1f3/Rorγ 1996 [ 140 ].
NR2A Nr2a1/Hnfα 1994 [ 141 ] Fatty acids ? [ 142 ]
Nr2a2/Hnfγ 1996 [ 143 ]
NR1I Nr1i3/Car 1994 [ 144 ] Xenobiotics and endobiotic [ 79 ]
Nr1i2/Pxr 1998 [ 145 , 146 , 147 , 148 ]
NR6A Nr6a1/Gcnf 1994 [ 149 ]
NR0B Nr0b1/Dax-1 1994 [ 150 ]
Nr0b2/Shp 1996 [ 151 ]
NR1H Nr1h2/Lxrβ 1995 [ 152 ] Oxysterols and bile salts [ 78 , 79 ]
Nr1h4/Fxrα 1995 [ 153 ]
Nr1h3/Lxrα 1995 [ 152 ]