Figure 1: SHP as a transcriptional regulator of miRNA expression. A) SHP inhibits ERRγ transactivation of the promoters of miR-433 and miR-127, which results in the repression of these two miRNAs. B) SHP activates miR-206 expression via a cascade dual inhibitory mechanism. The inhibition of ERRγ by SHP leads to decreased YY1 expression and the derepression of YY1 on AP1 activity, ultimately leading to the activation of miR-206. C) SHP inhibits p53 transactivation of the miR-34a promoter, resulting in the repression of miR-34a. D) SHP represses miR-200c expression by inhibiting the activity of PPARα and LRH-1.