Table 1: The surface volume in Å 3 occupied by the molecules that were selected as baseline in this study, telmisartan and GW590735 in the cognate and non-cognate PPAR α and γ_LBPs quantified in UCSF Chimera® [ 19 ].


Surface Volume (Å 3)

Cognate Non-cognate Protomol
Telmisartan 640.5 646.2 -
Protomol (telmisartan in cognate PPAR γ_LBP as described in pdb crystallographic deposition 3VN2) - - 1273
GW590735 646.6 626.8 -
Protomol (GW590735 in cognate PPAR α_LBP as described in pdb crystallographic deposition 2P54) - - 1145