Table 2: The binding scores of T-0901317 binding to LXRα (Kcal.mol −1) protein-ligand complexes were estimated using the FlexiDock program in SYBYL-X 2.0 (Tripos, St. Louis, MO).


Protein T-0901317

LXRα wild-type −2047
LXRα H383E −1421
LXRα E387Q −1332
LXRα H390E −1709
LXRα L414R −1891
LXRα R415A −1231