Table 1: Effect of SOF and DAC on hepatic Fibrosis degrees in each group.


Fibrosis grade  0  1  2  3  4  5  6  


Groups  
Control  10  0  0  0  0  0  0  
CCl _{4}  0  0  0  0  1 (%10)  3 (%30)  6 (%60)  ^{a} P≤ 0.001 
CCl _{4}+ SOF  0  0  0  5 (%50)  5 (%50)  0  0  ^{a,}b P≤ 0.001 
CCl _{4+}DAC  0  1 (10%)  8 (%80)  1 (%10)  0  0  0  ^{a,b,c} P≤ 0.001 
CCl _{4}+ SOF+DAC  0  0  9 (%90)  1 (%10)  0  0  0  ^{a,}b,c P≤ 0.001 
SOF+DAC  10  0  0  0  0  0  0  ^{b} P≤ 0.001 


CCI _{4} treated rates showed high grades of fibrosis. 90% of rats showed fibrosis at the 5 ^{th} and 6 ^{th} grade. SOF treated rats showed fibrosis ranged between the 3 ^{rd} and 4 ^{th} grade. DAC significantly prevent fibrosis progression. At least 80% of DAC treated rats expressed fibrosis at the 2 ^{nd} grade. Data are expressed as numbers of rats in each fibrosis grade and its percentages. The significance was determined using the Mann–Whitney test. Data were significantly different compared to ^{a} control rats, ^{b}CCI _{4} treated rats, ^{c}SOF treated rats, n = 10. 