Table 1: Effect of SOF and DAC on hepatic Fibrosis degrees in each group.


Fibrosis grade 0 1 2 3 4 5 6

Groups
Control 10 0 0 0 0 0 0
CCl 4 0 0 0 0 1 (%10) 3 (%30) 6 (%60) a P≤ 0.001
CCl 4+ SOF 0 0 0 5 (%50) 5 (%50) 0 0 a,b P≤ 0.001
CCl 4+DAC 0 1 (10%) 8 (%80) 1 (%10) 0 0 0 a,b,c P≤ 0.001
CCl 4+ SOF+DAC 0 0 9 (%90) 1 (%10) 0 0 0 a,b,c P≤ 0.001
SOF+DAC 10 0 0 0 0 0 0 b P≤ 0.001

CCI 4 treated rates showed high grades of fibrosis. 90% of rats showed fibrosis at the 5 th and 6 th grade. SOF treated rats showed fibrosis ranged between the 3 rd and 4 th grade. DAC significantly prevent fibrosis progression. At least 80% of DAC treated rats expressed fibrosis at the 2 nd grade. Data are expressed as numbers of rats in each fibrosis grade and its percentages. The significance was determined using the Mann–Whitney test. Data were significantly different compared to a control rats, bCCI 4 treated rats, cSOF treated rats, n = 10.