Figure 1: Effect of SOF and DAC on liver enzymes and fibrotic markers: DAC (30 mg/kg/day orally) either alone or combined with SOF (20 mg/kg/day orally) showed significant inhibitions of ALT and AST induced by CCl4 Figure 1-I-A&B. Figure 1-II-A illustrated the percent of fibrosis area calculated as collagen deposition spaces from three different films for each group of rats. Both drugs significantly inhibited expressions of HA (ng/gm protein) and MMP-9 Figure 1-II-B&C. Data are expressed as means ± SD. (n = 10). Value significantly different compared to aControl rats (p ≤ 0.05) aa(p ≤0.01) aaa(p ≤ 0.001) bCCI4 treated rats (p ≤ 0.05) bb(p ≤0.01) bbb(p ≤ 0.001) cSOF treated rats (p ≤ 0.05) cc(p ≤0.01) ccc(p ≤ 0.001) fDAC treated rats (p ≤ 0.05) ff(p ≤0.01) fff(p ≤ 0.001).