Figure 1: The effect of ginseng and ginseng nanoparticles on testicular histopathological changes induced by methotrexate in rats. (a) Control group, (b) Methotrexate group (20 mg/kg), (c) Ginseng (500 mg/kg/day) + Methotrexate (20 mg/kg) group, (d) Ginseng nanoparticles (250 mg/kg/day) + Methotrexate (20 mg/kg) group, (e) Ginseng nanoparticles (125 mg/kg/day) + Methotrexate (20 mg/kg) group. 1-Disruption of seminiferous tubules with irregularity in outline and shrinkage, 2-Severe disruption of seminiferous tubules with complete loss of spematogenic cell lines and Sertoli cells, 3-Shedding of the spermatogenic cells into the lumen giving vacoulated appearance in some seminiferous tubules, 4-Degeneration of Sertoli cells, 5-Interstitial edema, 6-Congested blood vessels, 7-Inflammatory cells, 8-Degeneration and loss of Leydig cells.