Table 2: Effect of oral administration of n-acetylcysteine on brain weight and brain weight/ body weight ratio in doxorubicin- induced neurotoxicity in rats.


Groups N Brain weight (g) Brain weight/ Body weight Ratio

Control 10 1.26 ± 0.07 0.48 ± 0.03
NAC treated 10 1.15 ± 0.09 0.44 ± 0.03
DOX-treated 7 1.64 ± 0.8* 1.15 ± 0.06*
DOX+NAC1 10 1.42 ± 0.06 a 0.09 ± 0.04 a
DOX+NAC2 9 1.46 ± 0.05 0.92 ± 0.04 a

Each value represents the mean ± SE. Data were analyzed by one-way ANOVA followed by Tukey post hoc test.
N = the number of animals in each group, NAC = n-acetylcysteine, DOX = doxorubicin, DOX+NAC1 = DOX+NAC treated group 1, DOX+NAC2 = DOX+NAC treated group 2.
*Significant difference at P < 0.05 Vs. Control group.
a Significant difference at P < 0.05 Vs. DOX-treated group.