Table 1: Effect of oral administration of n-acetylcysteine on body weight in doxorubicin- induced neurotoxicity in rats.


Groups N Initial body weight(g) Final body weight (g) Weight gain(g)

Control 10 172.75 ± 5.34 261.58 ± 4.48 86.51 ± 4.92
NAC treated 10 171.75 ± 5.06 262.70 ± 4.07 89.94 ± 5.92
DOX-treated 7 172.3 ± 4.23 143.36 ± 5.65 * −26.93 ± 1.75 *
DOX+NAC1 10 171.05 ± 5.33 159.50 ± 6.65 −10.56 ± 1.14 a
DOX+NAC2 9 172.5 ± 5.07 156.78 ± 5.34 −14.33 ± 1.06 a

Each value represents the mean ± SE. Data were analyzed by one-way ANOVA followed by Tukey post hoc test.
N = the number of animals in each group, NAC = n-acetylcysteine, DOX = doxorubicin, DOX+NAC1 = DOX+NAC treated group 1, DOX+NAC2 = DOX+NAC treated group 2.
*Significant difference at P < 0.05 Vs. Control group.
a Significant difference at P < 0.05 Vs. DOX-treated group.