Figure 6: Photomicrographs of the brain tissue showing effects of oral administration of n-acetylcysteine in doxorubicin-induced neurotoxicity in rats. (A) Brain tissue of the control group showing normal brain architecture; cortical neurons (n, arrow). Intercellular neuropils show different types of neuroglia and nerve fibers (p, arrow head). Blood vessels with narrow perivascular spaces (BV) (H&E x400). (B) Brain tissue of the NAC treated group showing normal brain architecture; the histological features as those found in the control group (H&E x400). (C) Brain tissue of the DOX-treated group showing severe histopathological alteration; most of the neurons appeared shrunken (n, arrow) with wide pericellular space (s, curve arrow), vacuolations in the neuropil (p, arrow head), blood vessels are surrounded by wide perivascular space (BV). (H&Ex400). (D) Brain tissue of the DOX+NAC1 group showing partial improvement as most of the neurons appeared similar to those of the control group with decreased pericellular spaces (n, arrow) (H&Ex400). (E) Brain tissue of the DOX+NAC2 group showing partial improvement as most of the neurons appeared similar to those of the control group with decreased pericellular spaces (n, arrow) but to a lesser degree than the previous group (H&Ex400).