Table 5: Effect of 4-aminopyridine (1, 2, and 4 mg/kg/s.c) (Kv channel blocker) with retigabine (8 mg/kg/i.p.) in maximal electroshock seizure test in mice.


Retigabine (8 mg/kg /i.p.) +4-aminopyridine (1,2,4 mg/kg/s.c) Percentage of convulsion in the (MES) model

1 mg/kg/s.c 66.7%
2 mg/kg/s.c 83.3%
4 mg/kg/s.c 100%