Table 1: Effect of diclofenac (10mg/kg/i.p.), retigabine (4mg/kg/i.p.), and their combination on mean latency period, frequency of convulsion, frequency of protection, and death rate in picrotoxin (5mg/kg/i.p.) induced convulsion in mice (model 1).


Group Parameter  Control group picrotoxin (N = 6)  Diclofenac group (N = 6)  Retigabine group (N = 6)  Combined group (N = 6)  P 


Latency period (min) Mean ± SE  7.92 ± 0.87 ^{ a }  9.31 ± 0.53 ^{ a }  37.46 ± 5.63 ^{ b }  No convulsion  $ <0.001** 
% of change  —  17.6%  373%  α  
Frequency of convulsion (%)  100% ^{ a }  100% ^{ a }  50% ^{ b }  0% ^{ c }  # <0.001** 
Frequency of Protection (%)  0% ^{ a }  0% ^{ a }  50% ^{ b }  100% ^{ c }  
% of change  —  0  50%  100%  
Death rate N (%)  100% ^{ a }  83.3% ^{ a }  0% ^{ b }  0% ^{ b }  # <0.001** 
% of change  —–  16.7%  100%  100%  


Groups with the same letters are statistically insignificant (p > 0.05).  
^{**}highly significant (p < 0.01). $: ANOVA (F) test. #: Chisquare test.  
N = the number of animals in each group.  
• Mean latency period is the mean period (min) between injection of picrotoxin and onset of convulsion.  
• Frequency of convulsion is the number of convulsed animals on the total number of animals.  
• Frequency of protection is the number of nonconvulsed animals on the total number of animals. 