Table 1: Effect of diclofenac (10mg/kg/i.p.), retigabine (4mg/kg/i.p.), and their combination on mean latency period, frequency of convulsion, frequency of protection, and death rate in picrotoxin- (5mg/kg/i.p.) induced convulsion in mice (model 1).


Group Parameter Control group picrotoxin (N = 6) Diclofenac group (N = 6) Retigabine group (N = 6) Combined group (N = 6) P

Latency period (min) Mean ± SE 7.92 ± 0.87 a 9.31 ± 0.53 a 37.46 ± 5.63 b No convulsion $ <0.001**
% of change —- 17.6% 373% α
Frequency of convulsion (%) 100% a 100% a 50% b 0% c # <0.001**
Frequency of Protection (%) 0% a 0% a 50% b 100% c
% of change 0 50% 100%
Death rate N (%) 100% a 83.3% a 0% b 0% b # <0.001**
% of change —– 16.7% 100% 100%

Groups with the same letters are statistically insignificant (p > 0.05).
**highly significant (p < 0.01). $: ANOVA (F) test. #: Chi-square test.
N = the number of animals in each group.
• Mean latency period is the mean period (min) between injection of picrotoxin and onset of convulsion.
• Frequency of convulsion is the number of convulsed animals on the total number of animals.
• Frequency of protection is the number of non-convulsed animals on the total number of animals.