Figure 2: Effect of venlafaxine and/or cysteamine on functional assessment of locomotor activity in CORT-induced anxiety/depression mouse model. Open field during the 20-min test: distance traveled (cm) (a) and velocity of locomotion (cm/sec) (b). Light-Dark Box during 10-min test: distance traveled (cm) (c) and velocity of locomotion (cm/sec) (d). Elevated plus maze during the 5-min test: distance traveled (cm) (e) and velocity of locomotion (cm/sec) (f). Values are mean ± SE (n = 8), analyzed by one-way ANOVA followed by Dunnett's multiple comparisons post hoc test. *P < 0.05 versus vehicle group, #P < 0.05 versus CORT group. OF: Open field, LDB: Light-Dark Box, EPM: Elevated plus maze, CORT: corticosterone, Ven low: Venlafaxine 10 mg/kg/day, Ven high: Venlafaxine 20 mg/kg/day, Cys: Cysteamine 150 mg/kg/day.