Table 2: Effect of diacerein (5, 10mg/kg) pretreatment on the hepatic MPO activity, MDA, GSH and nitrotyrosine levels in IR liver injury in rats.


Groups MPO(ng/g) tissue MDA(nmol/g) tissue GSH(nmol/g) tissue Nitrotyrosine (ng/mg) tissue

Sham 1.77 ± 0.9 4.56 ± 0.28 6.83 ± 0.63 0.04 ± 0.02
IR 7.34 ± 0.37 * 41.64 ± 1.76 * 3.39 ± 0.28 * 1.69 ± 0.13 *
Diacerein-SD 6.92 ± 0.46 # 37.36 ± 1.34 # 3.98 ± 0.39 # 1.29 ± 0.14 #
Diacerein-LD 2.35 ± 0.19 $ 8.23 ± 0.91 $ 5.98 ± 0.47 $ 0.62 ± 0.07 $
Data represent mean ± S.E.M.

*p<0.05 compared with sham group, #non-significant difference compared with IR group, $ p<0.05 compared with IR group.