Table 1: Effects of irbesartan (30mg/kg), pioglitazone (30mg/kg), and combination of irbesartan and pioglitazone in high dose and low dose on fasting blood glucose level (FBG) and 24-hour urinary albumin excretion (UAE), serum urea, and creatinine (mg/dl) in diabetic rats.


Parameters Groups FBG (mg/dl) Mean ± SE Urine albumin (mg/24 h) Mean ± SE Serum urea(mg/dl) Mean ± SE Serum creatinine(mg/dl) Mean ± SE

Control 88 ± 2.9 3.89 ± 2.3 36.4 ± 2.8 0.9 ± 0.06
DM group 200 ± 20.1 a 14.5 ± 1.1 a 145 ± 4.6 a 3.7 ± 0.17 a
Irbesartan-treated 190 ± 18.4 a 8.7.4 ± 0.45 a b 48.2 ± 3.1 b 2.1 ± 0.13 b
Pioglitazone-treated 112 ± 5.2 b c 7.2 ± 0.53 b 45.4 ± 2.9 b 2.3 ± 0.11 b
IRB+PIO high dose treated 105 ± 3.9 5.0 ± 0.4 b c d 42.1 ± 3.9 b c d 1.7 ± 0.1 b c d
IRB+PIO low dose treated 115 ± 4.1 a b 5.6 ± 0.45 b c d 39.1 ± 4.2 b c d 1.6 ± 0.1 b c d

aSignificant difference from control group.
bSignificant difference from diabetic group.
cSignificant difference from irbesartan group.
dSignificant difference from pioglitazone group.