Figure 3: Effects of irbesartan and pioglitazone on histopathological changes in aorta of diabetic rats. A) Cut section in the aorta of control rats showing a) intact flat endothelial cell lining, b) elastic media, and c) well fitted adventitia (H & E x 400). B) Cut section in aorta of diabetic rats showing a) ulcerated endothelial cells of the intima and b) formation of (spindle shaped) cholesterol clefts with degeneration (H & E x 400). C) Cut section in aorta of diabetic rats treated with irbesartan showing moderate decrease of the size of fatty streaks and foamy and inflammatory cell infiltration. Regeneration of the endothelial cells of the intima was observed (H & E x 40). D) Cut section in aorta of diabetic rats treated with pioglitazone showing moderate decrease of the size of fatty streaks and foamy and inflammatory cell infiltration. Regeneration of the endothelial cells of the intima was observed (H & E x 40). E) Cut section in aorta of diabetic rats treated with pioglitazone (30mg/kg/day) + irbesartan (30mg/kg/day) showing marked decrease of the size of fatty streaks and foamy and inflammatory cell infiltration. Regeneration of the endothelial cells of the intima was observed (H & E x 40). F) Cut section in aorta of diabetic rats treated with pioglitazone (15mg/kg/day) + irbesartan (5mg/kg/day) showing marked decrease of the size of fatty streaks and foamy and inflammatory cell infiltration. Regeneration of the endothelial cells of the intima was observed (H & E x 40).