Table 1: Effects of pentoxifylline (40 mg/kg), diltiazem (10mg/kg), and rosuvastatin (10mg/kg) on serum levels of urea and creatinine, sodium excretion, and K + excretion in STZ induced diabetic nephropathy in rats.


Groups Na + excretion (mmol/24h) K + excretion (mmol/24h) Serum urea (mg/dl) Serum creatinine (mg/dl)

Control 77.2 ± 5.31 60.5 ± 4.71 18.33 ± 1.1 1 ± 0.07
Diabetic control 23.41 ± 2.3 a 24.3 ± 2.11 a 120.22 ± 6.7 a 2.8 ± 0.1 a
PTX non-diab. 69.1 ± 4.2 55.9 ± 3.33 22.13 ± 1.3 0.9 ± 0.03
PTX diab. 57.8 ± 3.22 b 45.6 ± 2.82 b 45.77 ± 4.3 b 1.2 ± 0.5 b
Dilt non-diab. 68.3 ± 3.9 57.7 ± 3.11 31.74 ± 2.1 0.92 ± 0.02
Dilt diab. 29.33 ± 3.9 27.2 ± 2.7 113.3 ± 4.9 2.1 ± 0.4
Rosu. non-diab. 75.1 ± 6.1 61.3 ± 1.1 17.2 ± 1.3 1.1 ± 0.03
Rosu. diab. 61.4 ± 4.1 c 55.5 ± 2.7 c 40.4 ± 5.6 c 1.3 ± 0.01 c

a: Significant difference from control group.
b: Significant difference of PTX diabetic group from diabetic non-treated group.
c: Significant difference of rosuvastatin treated diabetic group from diabetic non-treated group.